Intraar­tic­u­lar appli­ca­tion of autol­o­gous con­di­tioned serum (ACS) reduces bone tun­nel widen­ing after ACL recon­struc­tive surgery in a ran­dom­ized con­trolled trial (pdf)

Nikica Dara­bos, Miroslav Haspl, Carsten Moser, Anela Dara­bos, Dubravka Bar­tolek, Diet­rich Groenemeyer

Pro-​inflammatory cytokines play a piv­otal role in osteoarthri­tis, as well as in bone tun­nel widen­ing after ACL recon­struc­tive surgery. A new treat­ment option is to admin­is­ter autol­o­gous con­di­tioned serum (ACS) con­tain­ing endoge­nous anti-​inflammatory cytokines includ­ing IL-​1Ra and growth fac­tors (IGF-​1, PDGF, and TGF-​b1, among oth­ers) in the liq­uid blood phase. The pur­pose of this trial was to estab­lish whether the post­op­er­a­tive out­come could be affected by intraar­tic­u­lar appli­ca­tion of ACS.

Effect of BMP-​12, TGF-​b1 and autol­o­gous con­di­tioned serum on growth fac­tor expres­sion in Achilles ten­don heal­ing (pdf)

Patri­cia E. Heis­ter­bach, Atanas Todorov, Rudolf Fluck­iger, Christo­pher H. Evans, Mar­tin Majewski

Achilles ten­don rup­tures are dev­as­tat­ing and recover slowly and incom­pletely. There is a great demand for bio­mol­e­c­u­lar ther­a­pies to improve recov­ery, yet lit­tle is under­stood about growth fac­tors in a heal­ing ten­don. Here, the role of growth fac­tors dur­ing ten­don heal­ing in a rat model and their reac­tion to sin­gle and mul­ti­ple growth fac­tor treat­ment are explored.

Treat­ment of knee osteoarthri­tis with Orthokine — derived auto­logu con­di­tioned serum (pdf)

Beth Anne Fox and Mary M Stephens

Osteoarthri­tis is the most preva­lent arthri­tis in the world with increas­ing num­bers of peo­ple expected to acquire the dis­ease as the pop­u­la­tion ages. Ther­a­pies com­monly used to man­age the dis­ease have lim­ited effi­cacy and some carry sign­f­i­cant risks. Cur­rent data sug­gest that the ant-​inflammatory cytokine IL-​1 recep­tor antag­o­nist (IL-​1Ra) can be alter the inflam­ma­tory response and car­ti­lage ero­sion present in OA. Intra-​articular gene expres­sion of IL-​1Ra has shown promis­ing results in ani­mal mod­els to pro­vide symp­tomic improve­ment and min­i­mize osteoarthritic changes.

Cytokines in Sports Med­i­cine — ISAKOS NEWSLET­TER 2014 — Cur­rent Con­cepts on Arthroscopy, Knee Surgery and Orthopaedic Sports Medicine(pdf)

Tahsin Beyzadeoglu and Murat Demirel

Cytokines are rel­a­tively small pro­tein mol­e­cules car­ry­ing sig­nals from cell to cell. The nomen­cla­ture of cytokines is het­ero­genic. Inter­leukins (IL) were num­bered in the order of their dis­cov­ery: IL-​1 to IL-​37.

Autol­o­gous con­di­tioned serum for the treat­ment of osteoarthri­tis and other pos­si­ble appli­ca­tions in mus­cu­loskele­tal dis­or­ders (pdf)

Anto­nio Frizziero, Erika Gian­notti, Francesco Oliva, Ste­fano Masiero, and Nicola Maffulli

The ther­a­peu­tic use of inter­leukin 1 (IL-​1) cytokine recep­tor antag­o­nists (IL-​1RA) has pro­moted the devel­op­ment of new bio­log­i­cal ther­a­pies for osteoarthri­tis (OA). Autol­o­gous con­di­tioned serum (ACS) is an alter­na­tive, safe and well-​tolerated treat­ment in OA. We per­formed a com­pre­hen­sive search of PubMed, Med­line, Cochrane, CINAHL, Embase, Sport­Dis­cus, Pedro and Google scholar data­bases using key­words such as ‘inter­leukin 1’, ‘osteoarthri­tis’ and ‘autol­o­gous con­di­tioned serum’.